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Human Y Chromosome Specific Single Nucleotide Polymorphisms
Stanford Reference: S97-248
Abstract
Stanford researchers have undertaken an ongoing systematic screening effort of the non-recombining portion of the human Y chromosome. As a result, they have successfully identified 148 single nucleotide polymorphisms that may be promising identification markers. Additionally, they have identified the geographic and ethnic distribution of the SNPs, which can be readily amplified by polymerase chain reaction.
Applications
- Initial filtering in DNA forensics
- Paternity testing
- Individual identification of sexual perpetrators
- Identification of non- and half-sibs
- Ethnicity affiliation estimation
Advantages
- Low cost, easy to genotype
- Readily amplified via PCR
Publications
- New publication note:
- Y-chromosome analysis urged for sex crimes. Nature, Vol. 413, Sept. 6, 2001, pg. 6.
- New publications:
- Underhill, PA; Passarino, G; Lin, AA; Shen, P; Mirazn Lahr, M; Foley, RA; Oefner, PJ; Cavalli-Sforza, LL. The phylogeography of Y chromosome binary haplotypes and the origins of modern human populations. Annals of Human Genetics 2001 Jan, 65(Pt 1):43-62.
- Seielstad, M.T., J.M. Hebert, A.A. Lin, P.A. Underhill. M. Ibrahim, D. Vollrath, and L.L. Cavalli-Sforza. 1994. Construction of human Y-chromosomal haplotypes using a new polymorphic A to G transition. Hum. Mol. Genet. 3: 2159-2161.
- Underhill, P. A., Jin, L., Zemans, R., Oefner, P. J. and Cavalli-Sforza, L. L. 1996. A pre-Columbian Y chromosome-specific transition and its implications for human evolutionary history. Proc. Natl. Acad. Sci. USA 93: 196-200.
- Underhill, P. A., Jin, L., Lin, A. L., Mehdi, S. Q., Jenkins, T., Vollrath, D., Davis, R., Cavalli-Sforza, L.L., and Oefner, P.J. 1997. Detection of numerous Y chromosome biallelic polymorphisms by denaturing high performance liquid chromatography. Genome Res. 7: 996-1005.
- Shen, P., Wang, F., Underhill, P.A., Franco, C., Yang, W.H., Roxas,, A., Sung, R., Lin, A.A., Hyman, R.W., Vollrath, D., Davis, R.W., Cavalli-Sforza,, L.L., Oefner, P.J. (2000), Population genetic implications from sequence variation in four Y chromosome genes. Proc. Natl. Acad. Sci. USA, 97, 7354-7359.
- Semino et al, The Genetic Legacty of Paleolithic Homo sapiens sapiens in Extant Europeans: A Y Chromosome Perspective. Science, Vol. 290, Nov. 10, 2000, pp. 1155-1159.
- Underhill et al, Y Chromosome sequence variation and the history of human populations, Nature Genetics, Vol. 26, Nov. 2000, pp. 358-361.
Continuing Research
- The researchers continue their work on deciphering human DNA sequence variation, analyzing Y chromosome variation, and cataloging the common sequence variation associated with human genes implicated in the susceptibility, resistance or environmental influences associated with disease in DNA isolated from geographically diverse human populations.
Innovators & Portfolio
Patent Status
Date Released: 08/12/1998
Licensing Contact
Kirsten Leute, Senior Associate
kirsten.leute@stanford.edu
1-650-723-4374
| S00-132 | | Multiplex Pyrosequencing for Typing | | S03-250 | | Somatic Recombination with MADM (Mosaic Analysis with Double Markers) | | S05-208 | | Thermosequencing: A Novel DNA Sequencing Method |
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S97-248
Human Y Chromosome Specific Single Nucleotide Polymorphisms
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