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High-density random-order array of magnetic beads for genotyping
Stanford Reference: S99-142
Abstract
This invention is a novel platform for generating microarrays of DNA and other biological molecules. Magnetic bead particles are now commonly used for DNA sample coupling, hybridization and cleanup protocols. This technology enables one to easily form high-density arrays (~ 10,000 features per mm2) of magnetic beads. This method of arraying magnetic beads provides a simple and very high throughput detection platform for nucleic acid analysis. A prototype chip with ~100,000 features has been fabricated and tested with commercially available functionalized magnetic beads. Fluorescently labeled beads were simply arrayed on the chip and detected with a conventional laser scanner.
Applications
- High throughput detection of DNA probes for genotyping and sequencing assays.
- Rapid detection of proteins, or other molecules coupled to magnetic beads.
Advantages
- Reusable with an easy wash step
- Simple fabrication process
- Compatibility with magnetic-bead-based DNA cleanup and hybridization protocols
- Enhanced sensitivity with integrated photodetectors
- Expandable to array-of-arrays, in industry standard formats, for ultra-high throughput
Publications
Innovators & Portfolio
Date Released: 10/18/2000
Licensing Contact
Kirsten Leute, Senior Associate
kirsten.leute@stanford.edu
1-650-723-4374
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S99-142
High-density random-order array of magnetic beads for genotyping
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